I'm talking about rather major changes.
For instance: Bleach has its filler arcs, but remains faithful to the manga all the same.
However, Full Metal Alchemist split off completely and introduced new characters, ultimately ending long before the manga and in (likely) a completely different fashion.
If the anime just left information out of the manga, that's not worth mentioning (too many series do that). I'm looking more for new things appearing in the anime.
